Born in Aleppo in 1949, Boghossian comes from a family of jewelers for which he worked while studying economics and sociology at Saint-Joseph University in Beirut. In 1975, the Lebanese civil war forced Boghossian to leave the country and settle in Belgium. More than three decades ago, Boghossian decided to enroll at the Academy of Fine Arts in Boitsfort, Brussels, while continuing to run the family business. In 1992, with his brother and father, he created the Boghossian Foundation at Villa Empain.
Overall, Boghossian is one of the few artists who experiments with applying fire and smoke to various works. Fire, being his preferred artistic language, is used through a wide range of torches and various other fire instruments. Having made a transition a little more than ten years ago towards abstraction, Boghossian's art can evoke a contemporary point of view on the Zero and Fluxus movement despite claiming that he does not belong to any artistic movement.

Objects that Boghossian attacked through the flame include canvas, paper, books, and plastics, sometimes leaving puncture patterns behind. In his paintings and drawings, Boghossian uses different media, including watercolor, charcoal, oil, pigments and acrylic paint, with techniques that include folding, collage and tearing. Boghossian's sculptures range from wood, polystyrene, clay, marble and bronze, some of which are also flame treated.